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KMID : 0613820060160060984
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Journal of Life Science
2006 Volume.16 No. 6 p.984 ~ p.988
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The Correlativity of Ulva lactuca Fractions, LPS, Enzymatic Activity and the Evaluation of Water Fraction
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Nam Chun-Suk
Kang Kum-Suk
Ha Jong-Myung
Lee Sang-Hyeon
Lee Jae-Hwa
Lee Dong-Geun
Jang Jeong-Su
Kang Hwan-Yul
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Abstract
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Lipopolysaccharide(LPS) was posttreated after the 14 day-pretreatment of Ulva lactuca fractions(ULF), and their correlativity to enzymatic activity alteration was investigated in the liver of rats. ULF was intraperitoneally administered into rats at dose of 1㎖/㎏ of 100 ㎎/㎏ concentration for 14 days. On the day 15, 1㎖/㎏ of LPS was injected. The corelativity was examined by measuring the changed values of superoxide dismutase(SOD) in mitochondrial fraction and catalase(CAT), glutathione peroxidase(GPx) in liver homogenate. The results showed that LPS treatment decreased the high values of SOD, CAT, GPx to the low values, but ULF pretreatment increased the low values of SOD, CAT, GPx to the high values. It was suggested that ULF, LPS and antioxidative enzymes like SOD, CAT, GPx had the corelativity of the high-low-high pattern and that the ULF pretreatment played the proper preventive role in the protection against the LPS treatment-induced enzymatic inactivity in the water fraction
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KEYWORD
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Ulva lactuca, fraction, lipopolysaccharide, enzymatic activity
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